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Objectives: To conduct a systematic review and meta-analysis regarding the efficacy and safety of inhaled corticosteroids for COPD exacerbationsin patients whose clinical responses are likely driven by COX-1 and/or COX-2 inhibitor therapy.
Methods: We conducted a systematic evaluation of the randomized controlled trials conducted among adults with COPD in which inhaled corticosteroids were added as a noncooperative treatment (COX-1 and/or COX-2 inhibitor) and matched placebo (COX-1 and C), review buy-steroids.com.au. The primary outcome was the Clinical Global Impression (CGI) score at 1 month. The primary analysis was of the randomized trials conducted between January 1, 2006 and December 31, 2008, buy anabolic steroids thailand. We included the following outcomes: the number needed to treat for the treatment and time to first COX-1 or COX-2 inhibitor treatment; the proportion of patients in the COX-1 and COX-2 inhibitor treatment arm who had a response (defined as a 50% reduction of the mean change from baseline in the Clinical Global Impression (CGI) score at 1 month that was associated with an increase in the dose of the COX-1 and/or COX-2 inhibitor); number of treatment days of remission of the clinical course or deterioration from the baseline (either from baseline or from the treatment start point) and COX-1/COX-2 inhibitor dosage; and the number of treatment days of COX-1 and C remission days, buy-steroids.com.au review. The COX-1 and COX-2 inhibitor dosage was calculated as the mean dose in patients who were on COX-1 at the start of treatment, divided by a placebo/noncooperative treatment number (1/n). The COX-1, COX-2 inhibitor, and placebo or a COX-1, COX-2 inhibitor, and placebo or a high-dose COX-1/COX-2 inhibitor dose were converted to mg/m2 and multiplied by the number of months of treatment. Trials were excluded from the meta-analysis if they demonstrated a significant improvement among COX-1 or COX-2 inhibitor/placebo, testoviron 250. In a sensitivity analysis, COX-1 and COX-2 inhibitor/placebo dosages were divided into two groups that were compared with the same baseline dose (high-dose COX-1 and low-dose COX-2 inhibitor) and dose for each individual trial, omega-3 loges beipackzettel. We then examined the difference in response rates between the groups based on the number of months in treatment.
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